For Patients: Ureaplasma urealyticum FAQ

Developed by the San Francisco Department of Public Health and California Prevention Training Center, this practical resource addresses frequently asked questions about the genital bacterium Ureaplasma urealyticum (UU), including:

  • What is UU?
  • Is it always harmful?
  • When are testing and/or treatment for UU recommended? (And when are they not?)

The goal is to help patients learn the facts about this common but often misunderstood bacterium.

For Providers: Ureaplasma urealyticum FAQ

Developed by the San Francisco Department of Public Health and California Prevention Training Center, this practical resource addresses frequently asked questions about the genital bacterium Ureaplasma urealyticum (UU), including:

  • When screening, testing, and/or treatment for UU are (and are not) recommended,
  • How to interpret positive test results in asymptomatic patients, and 
  • How to approach partner management.  

The goal is to help providers navigate the uncertainty around UU, avoiding unnecessary testing and treatment while ensuring appropriate treatment when indicated. 

Treatment Intervals: Syphilis in Pregnancy

Beautiful pregnancy of young family. Pregnant woman and man. Happy couple, wife and husband hugging tummy

Developed by the California Department of Public Health and the California Prevention Training Center, this resource for California providers discusses ideal, acceptable, not recommended, and inadequate benzathine penicillin G treatment intervals for pregnant patients with syphilis of late latent or unknown duration. In the state of California, strict 7-day intervals remain ideal, with 6–8-day intervals considered acceptable.

Available at: https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/Pregnancy-Tx-Intervals-Statement.pdf

Clinical Guidance: Infant and Child Follow-up After Exposure to Syphilis in Utero

Designed to support clinicians and public health practitioners, this resource provides detailed algorithms for the evaluation, treatment, and follow-up of neonates, infants, and children exposed to syphilis during pregnancy. Developed in alignment with the 2021 CDC STI Treatment Guidelines, the resource outlines step-by-step instructions for monitoring RPR/VDRL titers, interpreting titer trends, and ensuring thorough follow-up care for infants and children affected by syphilis.

3d illustration of a syphilis pathogen

Neisseria Gonorrhoeae (NG) Culture and Antimicrobial Susceptibility Testing (AST) Availability for California Providers

Designed for healthcare providers in California, this resource from the California Department of Public Health provides a detailed list of laboratories that offer Neisseria gonorrhoeae culture and/or antimicrobial susceptibility testing – both of which are recommended for managing suspected gonorrhea treatment failures and disseminated gonococcal infections.

various microscopic images of pathogens

CLIA-Waived Syphilis Point-of-Care Testing Options for Providers

This clinical resource outlines the CLIA-waived point-of-care testing options available for syphilis, including the Syphilis Health Check and the DPP HIV-Syphilis System. The document summarizes and compares the two CLIA-waived point-of-care tests, then answers frequently asked questions – including who can perform these tests, in what settings they may be most useful, and how to follow-up reactive point-of-care test results.

3d illustration of a syphilis pathogen

Opt-out screening is an approach where all patients are informed that HIV/STIs screening will be performed as part of routine medical care, unless the patient specifically declines. Included in the job aid are resources from various sources (including the CDC and CDPH), a workflow for a typical office visit, and guidelines for best practices.

Recent research has shown that opt-out guidelines increase screening rates and subsequent treatment for HIV and STIs (such as chlamydia, gonorrhea, and syphilis). This method reduces stigma, improves health equity, and opens the door for more comprehensive care.

Prenatal Syphilis Screening, Staging, and Management for Congenital Syphilis Prevention

This pocket guide summarizes all the essentials of prenatal syphilis screening, staging, and management with the goal of preventing congenital syphilis. 

various microscopic images of pathogens

CAPTC is pleased to announce two job aids, focused on mpox recognition, diagnosis, testing, treatment, and vaccination.

The shorter job aid is called “Mpox Clinical Recognition and Testing Quicksheet: Mpox Presentations vs. Common Exanthems.” It is intended as a print resource, to help facilitate clinical recognition of mpox in health care settings. The longer job aid, “Mpox Clinical Recognition and Testing Overview,” is intended as an electronic resource. It has links to a number of helpful mpox-related resources.

You can find the sources of images used in the quicksheet here:

How to Prescribe Expedited Partner Therapy (EPT) for Sexually Transmitted Infections 

Expedited Partner Therapy (EPT) is the clinical practice of treating sex partners of patients diagnosed with certain sexually transmitted infections (STIs) – including chlamydia (CT), gonorrhea (GC), and trichomoniasis – without the health care provider first examining the partner(s). EPT usually involves patient delivered partner therapy (PDPT), in which the patient delivers the medication or a prescription to their partner(s). While evaluating the partner and providing other needed health services would be ideal, this is often not feasible. EPT can be provided confidentially; it is effective, safe, acceptable to patients and partners, and helps to ensure timely partner treatment.

This resource contains information on how to prescribe EPT in California, including sample prescriptions, information on billing/reimbursement, and patient-facing materials.

For more information on EPT and why it should be prescribed, see “Expedited Partner Therapy (EPT) for Sexually Transmitted Infections: A Resource for California Health Care Providers – What is EPT and Why Should I Prescribe It?”

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