Topic: Clinical Tools and Guidelines
This guide was developed by our partners at the National Coalition for Sexual Health.
Sexual Health and Your Patients: A Provider’s Guide can help healthcare providers better integrate sexual health conversations and recommended preventive services into routine visits with adolescents and adults. By using this guide, providers can:
- Become more knowledgeable about sexual health
- Streamline their sexual history taking
- Increase their delivery of recommended preventive sexual health services by using “at a glance” tables
- Improve their care for LGBTQ+ patients
- Be better prepared to discuss sexual health topics and answer patient questions
California STI Treatment Recommendations in Pregnancy
These treatment regimens reflect the U.S. Centers for Disease Control and Prevention (CDC) STI Treatment Guidelines that are specific to pregnant people.

California STI/HIV Screening Recommendations in Pregnancy
Reflecting California HIV/STI screening recommendations for pregnant patients at various pregnancy stages.

April 2022 Seminar on PrEP Financing and Logistics
April 28, 2022
Opt-Out ED Screening for HIV, HCV, and Syphilis—Dear Colleague Letter from CDPH
March 28, 2022: Emergency departments (EDs) are uniquely positioned to identify people with syphilis, HIV, and hepatitis C who otherwise might remain undiagnosed. The California Department of Public Health (CDPH) recommends that EDs consider implementing routine opt-out testing for syphilis, HIV, and hepatitis C.
Identification and immediate treatment through the ED may have the added benefit of furthering health equity for those disproportionately affected by these infections

2021 CDC STI Treatment Guidelines Update: What’s New
December 10, 2021
Presented by Drs. Sharon Adler and Kelly Johnson
Learn more about the 2021 CDC STI Treatment Guidelines. Updated every 4-5 years, CDC’s STI Treatment Guidelines provide current evidence-based diagnostic, management, and treatment recommendations, and serve as a source of clinical guidance for managing sexually transmitted infections (STIs). This webinar will cover 2021 changes.
Learning Objectives
- Learn about and become proficient with the treatment updates
- Discuss and be able to share the rationale for the updates
- Understand the changes needed and apply them to clinical practice
2021 PrEP Clinical Practice Guideline – Clinical Providers’ Supplement
Updated Clinical Providers’ Supplement accompanying the 2021 PrEP Clinical Practice Guideline.
Updates for 2021 include:
- Checklist updated to include Descovy, 2-1-1 Truvada for MSM, and cabotegravir
- Added PrEP with intramuscular cabotegravir (CAB) injections (conditional on FDA approval) recommendation for HIV prevention in adults
- Added information about Descovy and cabotegravir to Patient Information Sheets

2021 PrEP Clinical Practice Guideline
Comprehensive information for the use of antiretroviral preexposure prophylaxis (PrEP) to prevent acquiring HIV infection.
Updates for 2021 include:
- A recommendation to inform all sexually active adults and adolescents about PrEP
- PrEP with intramuscular cabotegravir (CAB) injections (conditional on FDA approval) is recommended for HIV prevention in adults reporting sexual behaviors that place them at substantial ongoing risk of HIV exposure and acquisition.
Also view the updated PrEP Providers Supplement for 2021.

Comprehensive information for the use of antiretroviral preexposure prophylaxis (PrEP) to prevent acquiring HIV infection.
Updates for 2021 include:
- A recommendation to inform all sexually active adults and adolescents about PrEP
- PrEP with intramuscular cabotegravir (CAB) injections (conditional on FDA approval) is recommended for HIV prevention in adults reporting sexual behaviors that place them at substantial ongoing risk of HIV exposure and acquisition.
Also view the updated PrEP Providers Supplement for 2021.
California STI Treatment Guidelines Table for Adults and Adolescents—2021
These guidelines reflect the 2021 CDC STI Treatment Guidelines for adults and adolescents who are HIV negative as well as those with HIV.
