Clinical Guidance: Infant and Child Follow-up After Exposure to Syphilis in Utero

Designed to support clinicians and public health practitioners, this resource provides detailed algorithms for the evaluation, treatment, and follow-up of neonates, infants, and children exposed to syphilis during pregnancy. Developed in alignment with the 2021 CDC STI Treatment Guidelines, the resource outlines step-by-step instructions for monitoring RPR/VDRL titers, interpreting titer trends, and ensuring thorough follow-up care for infants and children affected by syphilis.